2-METHOXYETHYL CHLOROFORMATE Property

Boiling point:

157-158 °C(lit.)

Density 

1.192 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.4200(lit.)

Flash point:

138 °F

storage temp. 

2-8°C

solubility 

Soluble in most organic solvents.

form 

clear liquid

color 

Colorless to Light yellow

Sensitive 

Moisture Sensitive

CAS DataBase Reference

628-12-6(CAS DataBase Reference)

Safety

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2920 8/PG 2

WGK Germany 

3

F 

10-21

HS Code 

2918.99.5000

HazardClass 

6.1

PackingGroup 

II

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-METHOXYETHYL CHLOROFORMATE Chemical Properties,Usage,Production

Uses

Reactant for:• ;Preparation of N-bridged bicyclic sulfonamides as inhibitors of γ-secretase1• ;Preparation of dimethoxyethyl azodicarboxylate via amidation/oxidation and application to Mitsunobu reaction2• ;Regioselective, stereoselective, and kinetically-controlled nickel-catalyzed cyanoesterification of allenes chloroformates and TMSCN3• ;Preparation of amino carboxamidobenzothiazoles as Lck inhibitors4• ;Preparation of nonracemic spirooxindoles using a stereoselective three-component coupling reaction as the key step and using acylation reactions to add st

Uses

2-methoxyethyl chloroformate was used to produce di-2-dimethoxyethyl hydrazine carboxylate(alternative reagent for the mitsunobu reaction).